VPH NoE Exemplar Projects and the VPH ToolKit - 10. Environment for Sexually Transmitted Infection Modeling PDF | Print | E-mail

Article Index
VPH NoE Exemplar Projects and the VPH ToolKit
1. A multi-organ Core Model of arterial pressure and body fluids homeostasis
2. Integrated multi-level modelling of the musculoskeletal system
3. The Vertical and Horizontal Atherome (WHAM)
4. Multi-scale simulation and prediction of the drug safety problems related with hERG
5. Digital Patient Working Group: Modelling and visualising brain function and pathophysiology
6. Establishing ontology-based methods for the VPH ToolKit to improve interoperability between data and models: the Guyton case study
7. CIGENE: Integrating genetic theory and genomic data with multiscale models in a population context
8. USFD: The NoE, Infrastructure and the Challenge of Call6
9. VIP for VPH : Execution of medical image simulation workflows on DEISA through workflow interoperability between the Virtual Imaging Platform and the VPH toolkit
10. Environment for Sexually Transmitted Infection Modeling
11. Vascular Tissue Modeling Environment (VTME)
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10. "Environment for Sexually Transmitted Infection Modeling"

 

Coordinator: Martin Nelson, University of Nottingham, Centre for Mathematical Medicine & Biology

Partners: Queensland University of Technology, Australia.; Norwegian University of Science & Technology,Trondheim, Norway; Chlamydia Research Group, Arkansas Children’s Hospital Research Institute, Little Rock, Arkansas,USA

 

EP10 is developing an environment for mathematical/computational modeling of sexually transmitted infections (STIs). As a representative case study, the project focuses on mark-up and simulation of three existing “within-host” models of Chlamydia trachomatis infection – the most common sexually transmitted pathogen of humans, with over 90 million new adult cases occurring worldwide each year. These models deploy multiscale approaches to describe the spatial progression of C. trachomatis infection in the female genital tract, coupling a continuum description of extracellular Chlamydial particle motion to cell-scale and tissue-scale models of infection of the genital epithelium. Model simulations will be compared to experimental data for Chlamydia caviae infection in guinea pigs, a bacterial infection highly representative of C. trachomatis infection in humans. The study will demonstrate application of existing VPH toolkit software to the reproductive system, with a focus placed upon demonstrating the interoperability of tools across different spatial scales. While a focus upon C. trachomatis is proposed, the modeling approach should be extensible to other STIs, including gonorrhea and syphilis. The project will develop a computational tool for simulation of a range of STIs, coding each component of the proposed models independently to facilitate future uptake in the study of other infections. This STI modeling environment will facilitate efficient comparison of models and results, and will be deployable in identification of suitable vaccines.