VPH NoE Exemplar Projects and the VPH ToolKit - 6. Establishing ontology-based methods for the VPH ToolKit to improve interoperability between data and models: the Guyton case study PDF | Print | E-mail

Article Index
VPH NoE Exemplar Projects and the VPH ToolKit
1. A multi-organ Core Model of arterial pressure and body fluids homeostasis
2. Integrated multi-level modelling of the musculoskeletal system
3. The Vertical and Horizontal Atherome (WHAM)
4. Multi-scale simulation and prediction of the drug safety problems related with hERG
5. Digital Patient Working Group: Modelling and visualising brain function and pathophysiology
6. Establishing ontology-based methods for the VPH ToolKit to improve interoperability between data and models: the Guyton case study
7. CIGENE: Integrating genetic theory and genomic data with multiscale models in a population context
8. USFD: The NoE, Infrastructure and the Challenge of Call6
9. VIP for VPH : Execution of medical image simulation workflows on DEISA through workflow interoperability between the Virtual Imaging Platform and the VPH toolkit
10. Environment for Sexually Transmitted Infection Modeling
11. Vascular Tissue Modeling Environment (VTME)
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6, the selected Exemplar Project from the first call

6. Establishing ontology-based methods for the VPH ToolKit to improve interoperability between data and models: the Guyton case study

Lead: EBI Cambridge, This e-mail address is being protected from spambots. You need JavaScript enabled to view it

This Exemplar Project will investigate an interoperability framework for physiology models and gene expression data. In particular, this EP sets out to achieve the following goals:

i) the design and implementation of representational classes for the annotation of anatomy and physics in physiology model parameters and gene expression data;

ii) the demonstration and verification of such an approach via the annotation of (a) the parameters of a classic model that represents blood pressure regulation (namely, the Guyton model), implemented in the SAPHIR project (from the VPH NoE seedEP1) and marked up in the CellML repository, as well as (b) related human gene expression datasets in ArrayExpress that correspond to the anatomical locations these parameters address;

iii) the contribution of the outcomes of this work to the VPH toolkit effort, as a reference example of the role of a communal anatomical and physics framework for resource interoperability.