The May 2009 issue of Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences is now available online. The theme of this issue is ‘The virtual physiological human: tools and applications I’ and was compiled by David Gavaghan, Peter Coveney and Peter Kohl of the VPH NoE. Articles within this issue include research on CellML and FieldML, robust modelling on human and animal metabolic systems and different approaches to bone tissue engineering amongst other VPH related research.

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