New Phil Trans R Soc VPH Issue online now!
Phil Trans R Soc A Table of Contents for Theme Issue 'Towards the virtual physiological human: mathematical and computational case studies' compiled and edited by Bindi Brook, Peter Kohl and John King: 13 November 2011; Vol. 369, No. 1954
The new special VPH themed issue in the journal 'Philosophical Transactions of the Royal Society A' is now available online. This issue on mathematical and computational case studies was edited by Bindi Brook and John King (core partners of the VPH NoE) and Peter Kohl (founding member of the VPH NoE).
In this themed issue, they collate a series of case studies that use mathematical and computational modelling techniques to elucidate the processes underlying complex biological phenomena. Each paper suitably illustrates different key features that arise in the modelling process. The issue begins with a philosophical discussion of the problems faced when developing predictive models in the interdisciplinary region between the life and physical sciences, highlighting the challenge of assessing the validity of predictive models under circumstances in which preliminary observations are subject to severe uncertainty. The remaining nine papers demonstrate specific examples of model development, simulation and benchmarking with a strong emphasis placed upon model validation throughout. The selected case studies encompass a wide range of organs and systems studied via a wide range of predictive modelling strategies, including models of placental transport, pulmonary embolism, bone fracture and cochlea development, alongside cardiac simulation models and descriptions of the 'virtual patient' and the 'virtual athlete'.
Details of the issue are available from here