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 In  2008 the journal of the Royal Society Philosophical Transactions A (RSTA) started to host an annual two volume special issue entirely focused on the Virtual Physiological Human (VPH). These are the titles of the VPH special issues so far:

• 2008 vol I - Theme Issue ‘The virtual physiological human: building a framework for computational biomedicine I’ compiled by Marco Viceconti, Gordon Clapworthy, Peter Coveney and Peter Kohl; 
• 2008 vol II - Theme Issue ‘The virtual physiological human: building a framework for computational biomedicine II’ compiled by Marco Viceconti, Gordon Clapworthy, Peter Coveney and Peter Kohl;
• 2009 vol I - Theme Issue ‘The virtual physiological human: tools and applications I’ compiled by David Gavaghan, Peter Coveney and Peter Kohl;
• 2009 vol II - Theme Issue ‘The virtual physiological human: tools and applications II’ compiled by Peter Kohl, Peter Coveney and David Gavaghan;
• 2010 vol I - Theme Issue 'The virtual physiological human: computer simulation for integrative biomedicine I' compiled and edited by Marco Viceconti and Peter Kohl; (Now available online and free until July 2010!)

• 2010 vol II - Theme Issue 'The virtual physiological human: computer simulation for integrative biomedicine II' compiled and edited by Peter Kohl and Marco Viceconti (Now available online and free until July 2010!)

In celebration of the Royal Society’s 350^th anniversary (http://royalsocietypublishing.org/seefurther) all articles in the 2010  double issue (along with all our content back to 1665) are free to access up until the end of July 2010. The print issues are available at the special price of £47.50 each. You can order them online via the above web page (enter special code TA 1920 or TA 1921 when prompted) or, alternatively, you can contact This e-mail address is being protected from spambots. You need JavaScript enabled to view it

The past year has been an extremely successful year for the Royal Society journals. Over the past twelve months, they report that they have witnessed an impressive rise in submissions, as well as an exceptional rise in article downloads, citations and Impact Factors. The Royal Society Publishing has provided the RSTA citation statistics for 2009. Among the 10 most cited papers,  four are from the 2009 VPH special two volume issue.  These articles will be freely available online throughout 2010.

A systems perspective on the effective connectivity of overt speech production (2009 vol II) Simon Eickhoff, Stefan Heim, Katrin Amunts

CellML metadata standards, associated tools and repositories (2009 vol I) Daniel Beard, Randall Britten, Mike Cooling, Alan Garny, Matt Halstead, Peter Hunter, James Lawson, Catherine Lloyd, Justin Marsh, Andrew Miller, David Nickerson, Poul Nielsen, Taishin Nomura, Shankar Subramanium, Sarala Wimalaratne and Tommy Yu

CELLULAR OPEN RESOURCE (COR): current status and future directions (2009 vol I) Alan Garny, Denis Noble, Peter Hunter and Peter Kohl

Generation of histo-anatomically representative models of the individual heart: tools and application (2009 vol II). Gernot Plank, Rebecca Burton, Patrick Hales, Martin Bishop, Tahir Mansoori, Miguel Bernabeu, Alan Garny, Anton Prassl, Christian Bollensdorff, Fleur Mason, Fahd Mahmood, Blanca Rodriguez, Jürgen Schneider, David Gavaghan and Peter Kohl

There have also been other articles outside of the two volume special issues in RSTA and these are detailed below:

Fenner, J.W., Brook, B., Clapworthy, G., Coveney, P.V., Feipel, V., Gregersen, H., Hose, D.R., Kohl, P., Lawford, P., McCormack, K.M., Pinney, D., Thomas, S.R., Van Sint Jan, S., Waters, S., & Viceconti, M. 2008. The EuroPhysiome, STEP and a roadmap for the virtual physiological human. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 366, (1878) 2979-2999 (doi: 10.1098/rsta.2008.0089) available from here

Hunter P, Coveney PV, de Bono B, Diaz V, Fenner J, Frangi AF, Harris P, Hose R, Kohl P, Lawford P, McCormack K, Mendes M, Omholt S, Quarteroni A, Skar J, Tegner J, Randall Thomas S, Tollis I, Tsamardinos I, van Beek JHGM, and Viceconti M. 2010. A vision and strategy for the virtual physiological human in 2010 and beyond. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 368:2595-2614 available from here

Hofmann-Apitius, M., Fluck, J., Furlong, L., Fornes, O., Kolarik, C., Hanser, S., Boeker, M., Schulz, S., Sanz, F., Klinger, R., Mevissen, T., Gattermayer, T., Oliva, B., & Friedrich, C.M. 2008. Knowledge environments representing molecular entities for the virtual physiological human. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 366, (1878) 3091-3110 (doi: 10.1098/rsta.2008.0099) available from here

Garny, A., Cooper, J., Hunter, P.J.2009. Towards a VPH/Physiome Toolkit. Systems Biology and Medicine (doi: 10.1002/wsbm.63) available from here

Kohl, P. & Noble, D. 2009. Systems biology and the Virtual Physiological Human. Molecular Systems Biology, 5: 292 (doi:10.1038/msb.2009.51) available from here

Kohl P, Crampin EJ, Quinn TA, Noble D. 2009. Systems Biology: an approach. Clinical Pharmacology & Therapeutics (2010) 88 1, 25–33. (doi:10.1038/clpt.2010.92) available from here.

Sadiq, S.K., Mazzeo, M.D., Zasada, S.J., Manos, S., Stoica, I., Gale, C.V., Watson, S.J., Kellam, P., Brew, S., & Coveney, P.V. 2008. Patient-specific simulation as a basis for clinical decision-making. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 366, (1978) 3199-3219 (doi: 10.1098/rsta.2008.0100) available from here

Stoica, I., Sadiq, S.K., Gale, C.V., & Coveney, P.V. 2008. Virtual Physiological Human research initiative: the future for rational HIV treatment design? Future HIV Therapy, 2, (5) 419-425

Viceconti, M., Clapworthy, G., & Van Sint Jan, S. 2008a. The European Virtual Physiological Human. J Med Biomech 23, 19-25

 Viceconti, M., Clapworthy, G., & Van Sint Jan, S. 2008b. The Virtual Physiological Human — A European Initiative for in silico Human Modelling. Journal of Physiological Sciences, 58, (7) 441-446 (doi:10.2170/physiolsci.RP009908) available from here